With issue #10 (Oct. 1972), the series began featuring new material. Issues #10-19 featured the swamp creature the Man-Thing, continuing from his introduction in the black-and-white comics-magazine Savage Tales #1 (May 1971). Following a story written by Man-Thing co-creator Gerry Conway, scripting was taken over by Steve Gerber, for whom the feature and eventual comic-book series Man-Thing would prove a signature work. Through issue #14, a back-up reprint story would be featured, similar to those that appeared in the first nine issues.
The story in #19 (Dec. 1973) introduced Howard the Duck, a cynical, cigar-smoking, anthropomorphic water fowl — a parody of funny animals — intended as a throwaway character. That plan changed when the duck quickly proved popular; it would eventually one of Marvel's biggest 1970's characters and a pop-culture phenomenon that would later get a solo series as well as a notoriously disastrous feature film.
Morbius, the Living Vampire, introduced in The Amazing Spider-Man #101 (Oct. 1971), became the starring feature with Adventure into Fear #20 (Feb. 1974), and continued through the rest of the run. After a single issue by writer Mike Friedrich and penciller Paul Gulacy, Steve Gerber wrote several issues in which Morbius went on a picaresque interdimensional journey. Doug Moench and Bill Mantlo followed as the feature's writers. Artists included Gil Kane, P. Craig Russell, Frank Robbins, George Evans, and Don Heck.