The TV show was devoted to a superheroine who got her powers by invoking the ancient Egyptian goddess of the same name. High school science teacher Andrea Thomas found a mysterious amulet during an archaeological dig in Egypt, and found it would turn her into a modern incarnation of the goddess.
When danger was imminent, Thomas would reveal her amulet and intone an incantation; a bright light would flash and she would be transformed into her super-powered alter-ego.
The show was closely linked with a similar TV program, Shazam!, which also was a live-action superhero show produced by Filmation. The two would later be linked as The Shazam/Isis Hour.
The last issue of the comic book series coincided neatly with the last appearance of the character on Saturday morning TV.