The character of Vampirella first appeared as a horror-story hostess in Vampirella #1 (Sept. 1969), continuing in that capacity through issue #8 (Nov. 1970) when she was 'revamped' as a leading character.
Vampirella initially appeared in Warren Publishing's Vampirella #1 (Sept. 1969) and lasted until issue #112 (1983). The title was a sister magazine of Warren's horror-comics magazines Creepy and Eerie. Like those magazines' respective mascots, Uncle Creepy and Cousin Eerie, Vampirella hosted anthological horror stories. Unlike the other two hosts, Vampirella would also star in her own story, which would headline each issue. Vampirella was initially edited by Bill Parente. It would later be edited by Archie Goodwin (issues #7-12, 34-5), Billy Graham (#13-16), Bill DuBay (#21-50, 87-95, 101-102) and Louise Jones (#51-86).
The first artists for Vampirella were Frank Frazetta (the premiere cover) and Tom Sutton (interior art). Jose Gonzalez became the character's primary artist starting with issue #12. Other artists who would draw Vampirella during her magazine's original run included Gonzalo Mayo, Leopold Sanchez, Esteban Maroto, José Ortiz, Escolano, Rudy Nebres, Ramon Torrents, Pablo Marcos, Jim Janes, John Lakey and Val Lakey.
Backup features appearing in Vampirella included "Tomb of the Gods," "Pantha," and "Fleur". Vampirella herself also appeared in a story with fellow Warren characters Pantha and The Rook in Eerie #94-95, and with most of the Warren characters in a company crossover special in Eerie #130. The final issue of the original Vampirella was cover-dated March 1983.