The bi-monthly science-fiction comic, published by Bill Gaines and edited by Al Feldstein, originated as the comic A Moon, A Girl... Romance, which was retitled and changed to a science fiction comic in May, 1950. Although the title change took effect with issue 13, Gaines and Feldstein decided not to restart the numbering in order to save money on second class postage. The Post Office took note and starting with issue 6 on, all the issues were numbered correctly. Over a four-year span the comic ran for 22 issues, ending with the November-December, 1953 issue.
Cover illustrations were by Feldstein with the exception of two by Joe Orlando, one collaboration by Feldstein and Al Williamson, plus another collaboration by Williamson with Frank Frazetta. Artists who drew stories for this EC title were Feldstein, Frazetta, Williamson, Orlando, Wally Wood, Harvey Kurtzman, George Roussos, Harry Harrison, Reed Crandall, Will Elder, Bernard Krigstein, Jack Kamen, John Severin, and Mac Elkin.
The companion comic for Weird Fantasy was Weird Science. The two titles merged in 1954 to become Weird Science-Fantasy due to lack of sales. Weird-Science Fantasy ran for seven issues before a title change to Incredible Science Fiction for four issues.
Issue 13's ''Home to Stay'' was an unauthorized adaptation of two Ray Bradbury stories, ''The Rocket Man'' and ''Kaleidoscope''. Bradbury contacted EC about this and they eventually reached an agreement for the comics to feature official adaptations of Bradbury's work. Adapted stories include issue 17's ''There Will Come Soft Rains'', issue 18's ''Zero Hour'', issue 19's ''King of the Grey Spaces'', issue 20's ''I, Rocket'', issue 21's ''The Million Year Picnic'' and issue 22's ''The Silent Towns''.