The character was introduced in 1972 due mainly to the fact that the previous year, the Comics Code Authority had relaxed its decades-long restrictions on monsters appearing in newsstand comics, so that Marvel felt comfortable enough to launch a plethora of titles featuring the classic movies monsters, which also included Frankenstein, the Tomb of Dracula, and the Mummy appearing in Supernatural Thrillers. The monsters would also appear in a number of magazines published by Marvel, such as Vampire Tales.
The comic mainly dealt with the plight of Jack Russell, who once a month was transformed into a werewolf, and his efforts to rid himself of the curse, as well as the inevitable conflicts in which his hairy alter-ego found himself. The werewolf naturally found himself battling other werewolves, evil cultists, even Dracula.
Issue #32 (August 1975) introduced an antagonist named Moon Knight who would eventually become a very popular Marvel superhero with his own title in the following decade.